2012
Rand U., Rinas M., Schwerk J., Nöhren G., Linnes M., Kröger A., Flossdorf M., Kály-Kullai K., Hauser H., Höfer T.* and Köster M.* (2012) Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Mol. Syst. Biol. in press (*corresponding authors).
Alberghina, L., Höfer, T. and Vanoni, M. (2012) Systems biology for biomedical innovation. Biotecnol. Adv. 30, 1-3.
2011
Sancar, G., Sancar, C., Brügger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik S., Lohmann, I., Wieland, F., Hoefer, T., Diernfellner, A., Brunner, M. (2011) A global circadian repressor controls anti-phasic expression of metabolic genes in Neurospora. Mol Cell 44, 687-697.
Querfurth, C., Diernfellner, A., Gin, E., Höfer, T. and Brunner, M. (2011) Circadian conformational change of the Neurospora clock protein FREQUENCY triggered by clustered hyperphosphorylation of a basic domain. Mol. Cell 43, 712-722.
Deswal, S., Schulze, A., Höfer, T. and Schamel, W.W. (2011) Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks. PLoS ONE 6:e22928
2010
Salazar, C., Brümmer, A., Alberghina, L. and Höfer, T. (2010) Timing control in regulatory networks by multisite protein modifications. Trends Cell Biol. 20, 634-41.
Nika, K., Soldani, S., Salek, M., Gray, A., Etzensperger, R., Fugger, L., Polzella, P., Cerundolo, V., Dushek, O., Höfer, T., Viola, A. and Acuto, O. (2010) Constitutive high levels of activated Lck drive T cell antigen receptor signal transduction. Immunity 32, 766-777.
Luijsterburg, M.S., von Bornstaedt, G., Gourdin, A.M., Politi, A.Z., Moné, M.J., Warmerdam, D.O., Goedhart, J., Vermeulen, W., van Driel, R. and Höfer, T. (2010) Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. J. Cell Biol. 189, 3445-3463.
Brümmer, A., Salazar, C., Zinzalla, V., Alberghina, L., Höfer, T. (2010) Mathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplication. PLoS Comp. Biol. 6:e1000783.
Mariani, L., Schulz, E., Lexberg, M., Helmstetter, C., Radbruch, A., Löhning, M., and Höfer, T. (2010) Short-term memory in gene induction reveals the regulatory principle behind stochastic interleukin-4 expression. Mol. Syst. Biol. 6:359.
Busse, D., de la Rosa, M., Hobiger, K., Thurley, K., Floßdorf, M., Scheffold, A. and Höfer, T. (2010) Competing feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular microenvironments. Proc. Natl. Acad. Sci. USA 107, 3058–3063.
Stittrich, A., Haftmann, C., Sgouroudis, E., Kühl, A.A., Hegazy, A.N., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G.A., Li, N., Fang, Z., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F.M., Baumgrass, R., Bosio, A., Mollenkopf, H., Grün, J., Thiel, A., Chen, W., Höfer, T., Loddenkemper, C., Löhning, M., Chang, H., Rajewsky, N., Radbruch, A. and Mashreghi, M.F. (2010) MicroRNA-182 is induced by interleukin-2 and promotes clonal expansion of activated T helper lymphocytes. Nat. Immunol. 11, 1057-62.
2009
Schulz, E., Mariani, L., Radbruch, A., and Höfer, T. (2009) Sequential polarization and imprinting of T-helper type 1 differentiation by interferon-γ and interleukin-12. Immunity, 30, 673-683.
Diernfellner, A., Querfurth, C., Salazar, C., Höfer, T. and Brunner, M. (2009) Phosphorylation modulates rapid nucleo-cytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale. Genes Dev. 23, 2192-2200.
Alberghina, L., Höfer, T., and Vanoni, M. (2009) Molecular networks and system-level properties. J. Biotechnol. 144, 224-233.
Dinant, C., Luijsterburg, M.S., Höfer, T., Von Bornstaedt, G., Vermeulen, W., Houtsmuller, A.B. and Van Driel, R. (2009) Assembly of multi-protein complexes that control genome function. J. Cell Biol. 185, 21-26.
Salazar, C. and Höfer, T. (2009) Multisite protein phosphorylation: From molecular mechanisms to kinetic models. FEBS J., 276, 3177-3198.
Figueiredo, S., Höfer, T., Klotz, C., Sers, C., Hartmann, S., Lucius, R., and Hammerstein, P. (2009) Modelling IL-10 regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes. FEBS J., 276, 3454-3469.
Roszol, L., Kaly-Kullai, K., Volford, A. (2009) Chemical waves in inhomogeneous media with circular symmetry. Chemical Physics Letters 478 (1-3), 75-79. Reprint (0.4 MB)
2008
Salazar, C., Politi, A., and Höfer, T. (2008) Decoding of Ca2+ oscillations by phosphorylation cycles: analytic results. Biophys. J. 94:1203-1215.
Löhning, M., Hegazy, A.N., Pinschewer, D.D., Busse, D., Lang, K.S., Höfer, T., Radbruch, A., Zinkernagel, R.M, and Hengartner, H. (2008) Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J. Exp. Med. 205, 53-61.
Matthäus F., Salazar C. and Ebenhöh O. (2008) Biosynthetic potentials of metabolites and their hierarchical organization. PLoS Comput. Biol. 4, e1000049
2007
Scheffold, A., Murphy, K.M., and Höfer, T. (2007) Competition for cytokines: Treg cells take all. Nat. Immunol. 8, 1285-1287.
Podtschaske, M., Benary, U., Zwinger, S., Höfer, T., Radbruch, A., and Baumgraß, R. (2007) Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression. PLoS ONE 2, e935.
Salazar, C. and Höfer, T. (2007) Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein-protein interactions. FEBS J. 274, 1046-1061.
Höfer, T. (2007) In remembrance: Reinhart Heinrich 1946-2006. PLoS Comput. Biol. 3, e18.
Selected publications before 2007
Politi, A., Gaspers, L.D., Thomas, A.P., and Höfer, T. (2006) Models of IP3 and Ca2+ oscillations: Frequency encoding and identification of underlying feedbacks. Biophys. J. 90, 3120-3133.
Höfer, T., Mühlinghaus, G., Moser, K., Yoshida, T.E., Mei, H., Hebel, K., Hauser, A., Hoyer, B., Luger E., Dörner, T., Manz, R.A., Hiepe, F., and Radbruch A. (2006) Adaptation of humoral memory. Immunol. Rev. 211, 295-302.
Scheffold, A., Hühn, J., and Höfer, T. (2005) Regulation of CD4+CD25+ regulatory T cell activity: It takes IL-2 to tango. Eur. J. Immunol. 35, 1336-1361.
Mariani, L., Löhning, M., Radbruch, A., and Höfer, T. (2004) Transcriptional control networks of cell differentiation: Insights from T lymphocytes. Progr. Biophys. Mol. Biol. 86, 45-76.
Salazar, C. and Höfer, T. (2003) Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis. J. Mol. Biol. 327, 31-45.
Höfer, T., Nathanson, H., Löhning, M., Radbruch, A., and Heinrich, R. (2002) GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model. Proc. Natl. Acad. Sci. USA 99, 9364-9368.
Höfer, T., Venance, L., and Giaume, C. (2002) Control and plasticity of intercellular calcium waves in astrocytes: a modeling approach. J. Neurosci. 22, 4850-4859.
Schuster, S., Marhl, M., and Höfer, T. (2002) Modelling of simple and complex calcium oscillations: From single-cell responses to intercellular signalling. Eur. J. Biochem. 269, 1333-1355.
Höfer, T., Politi, A., and Heinrich, R. (2001) Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: A theoretical study. Biophys. J. 80, 75-87.
Höfer, T. (1999) Model of intercellular calcium oscillations in hepatocytes: synchronization of heterogeneous cells. Biophys. J. 77, 1244-1256.
Höfer, T. and Maini, P.K. (1996) Turing patterns in fish skin. Nature 380, 678.
Höfer, T., Sherratt, J.A., and Maini, P.K. (1995) Dictyostelium discoideum: Cellular self-organization in an excitable biological medium. Proc. Roy. Soc. Lond. B 259, 249-257.
